BCL2 Protein Family: Essential Regulators of Cell Death by Claudio Hetz

By Claudio Hetz

During this e-book, scientists pioneering the sphere have compiled a sequence of targeted chapters to focus on the relevance of the BCL‑2 family members of proteins in apoptosis, body structure and affliction. a huge concentration of this quantity is thinking about the capability TH period PEUT IC advantages of concentrating on apoptosis pathways within the context of human disorder. Readers drawn to knowing how a telephone handles rigidity and the implications of dysregulation of this technique for human ailment will locate this publication very invaluable. It makes an attempt to explain a desirable quarter of study the place body structure and biomedicine converge at diversified degrees, revealing a visit from the molecular law of apoptosis to the influence of this method to the body structure of an entire organism.

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Mol Cell 2004; 16(1):59-68. 110. Tondera D, Czauderna F, Paulick K et al. The mitochondrial protein MTP18 contributes to mitochondrial fission in mammalian cells. J Cell Sci 2005; 118(Pt 14):3049-3059. 111. Tondera D, Santel A, Schwarzer R et al. Knockdown of MTP18, a novel phosphatidylinositol 3-kinase-dependent protein, affects mitochondrial morphology and induces apoptosis. J Biol Chem 2004; 279(30):31544-31555. 112. Taguchi N, Ishihara N, Jofuku A et al. Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.

J Cell Biol 2006; 174(7):915-921. 37. de Brito OM, Scorrano L. Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature 2008; 456(7222):605-610. 38. Simmen T, Aslan JE, Blagoveshchenskaya AD et al. PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis. EMBO J 2005; 24(4):717-729. 39. Berridge MJ, Bootman MD, Roderick HL. Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 2003; 4(7):517-529. 40. Orrenius S, Zhivotovsky B, Nicotera P.

Cell 2006; 126(1):163-175. 94. Frezza C, Cipolat S, Martins de Brito O et al. OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell 2006; 126(1):177-189. Homeostatic Functions of BCL-2 Proteins beyond Apoptosis 27 95. Hermann GJ, Thatcher JW, Mills JP et al. Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. J Cell Biol 1998; 143(2):359-373. 96. Koshiba T, Detmer SA, Kaiser JT et al. Structural basis of mitochondrial tethering by mitofusin complexes.

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BCL2 Protein Family: Essential Regulators of Cell Death by Claudio Hetz
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