By Dominique Forget
« On fait des enfants pour soi, pour donner de soi, pour mettre un peu de soi dans nos familles et nos sociétés et pour faire que soi existe encore un peu après sa mort. » Extrait de los angeles préface du Dr Jean-François Chicoine Il est grand, le désir d’enfants… Mais jusqu’où sommes-nous prêts à aller, individuellement et collectivement, pour assouvir ce désir irrépressible ? Fécondation in vitro, congélation d’embryons, sélection génétique, banques d’ovules et de spermatozoïdes, dons d’embryons, mères porteuses, homoparentalité et grossesses tardives sont à l’honneur dans cet essai à saveur d’enquête journalistique, qui se lit d’un trait. Dans un type ciselé et efficace, l’auteure Dominique overlook livre les résultats de ses recherches, de même que les confidences parfois troublantes qu’elle a recueillies auprès de femmes et d’hommes qui ont fait l’expérience de l. a. procréation assistée, souvent au prix d’énormes sacrifices. Elle disclose également l’état de los angeles réglementation en matière de procréation assistée au Québec, au Canada et ailleurs dans le monde, et rapporte les propos d’experts qui ont pris place dans les débats entourant los angeles procréation assistée. Dérangeant, voire profondément bouleversant, Bébés illimités est un livre-choc qui nous laisse avec de grandes réflexions…
À propos de Dominique Forget
Titulaire d’une maîtrise en génie chimique, Dominique overlook travaille depuis plus de dix ans comme journaliste scientifique. Elle collabore à de nombreux magazines dont L’actualité, Québec technology et Elle Québec. Membre de l. a. Fédération professionnelle des journalistes du Québec et de l’Ordre des ingénieurs du Québec, elle est également l’auteure de Perdre le Nord ?, ouvrage qui a remporté en 2008 le prix du meilleur livre scientifique canadien, dans l. a. catégorie « grand public », décerné par l’Association canadienne des rédacteurs scientifiques.
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Example text
5). Hypothetically, one of these pathways includes removal of the propeptide, leading to processing of carbohydrates into some complex forms, while the other one involves protein with retained propeptide resulting in conservation of high mannose oligosaccharides only (Fig. 5). 28 Urban Gullberg et al. S Is Sorting Dependent on Processing? Constitutive secretion of both lysosomal and azurophil granule proteins seems to be limited to unprocessed proforms. Therefore, recognition for sorting to granules could be specific for processed forms and processing would then be a prerequisite for sorting to granules.
A 125 amino acid aminoterminal propeptide, a small peptide between the light and heavy chains, as well as a single serine residue of the carboxy terminus are each excised during processing of proMPO into mature MPO. Similar to the maturation of serine proteases, proteolytic processing occurs in post-endoplasmic reticulum (post-ER) compartments, but mature MPO has been found to be sensitive to digestion with endoglycosidase H (Endo H), indicating Urban Gullberg et al. 26 - light heavy propeptide subunit ((3) subunit (11) Translocation into ER Cleavage of signal peptide signal peptide ERI Goigi Acquisition of N·linked carbohydrates which are partially processed into complex forms oli osaccharides [.
Autocatalytic cleavage of MPO between Met 409 and 6 4 5 1 2 3 Pro 410 due to the presence of the sulfonium linkage. Natural, recombinant and mutant MPO (5 g) were dissolved in sample buffer without beta-mercapto94 - ethanol and heated at 90°C for 67 _ 8 min, and analyzed by SDSPAGE. Lane 2 the heating of natural MPO resulted in a frag43 ment of 38 kDa. 1 with the light and heavy subunit. Lane 4 the autolytic cleavage was not observed in the mutant Met 409Gln. Lane 5 as a control, this cleavage occurred in the close mutant Glu 408Gln.
