By Erik De Clercq (auth.), Erik D. A. De Clercq, Anne-Mieke I. Vandamme (eds.)
HIV an infection has been a better problem to present drugs than the other viral sickness ofmodem occasions. HIV results in a power an infection and the virus has a big genetic flexibility less than selective strain. in the course of its copy tive cycle in sufferers, HIV accumulates mutations at this kind of excessive cost that the selective strain inflicted at the immune method, or generated through antiviral medications swiftly triggers the looks of break out mutants. at the moment on hand medicinal drugs, while used singly, usually are not able to suppressing virus replication in sufferers to any such point that the new release of mutations, from which a version proof against immune assault or antiviral medicines may be chosen, is avoided. this is often the most for the reason that mixture remedy, often of 3 medications, has turn into the normal technique for the therapy ofAIDS. it's noticeable that virus eradication won't simply be plausible, in order that medicines must be taken for a protracted time or maybe lifelong that allows you to hold the viral load as little as attainable. even if the presently used drug mixtures might be in a position to regulate virus replication in a selected sufferer for this kind of seasoned longed time period is determined by many elements, such a lot of that are addressed within the diversified chapters of this ebook. the purpose of antiviral drug blend remedy for AIDS is eventually to revive complete functionality of the immune system.
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Extra resources for Combination Therapy of AIDS
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Lancet 353: 863-868 37 Lucas GM, Chaisson RE, Moore RD (1999) Highly active antiretroviral therapy in a large urban clinic: risk factors for virologic failure and adverse drug reactions. Ann Intern Med 131: 81-87 38 D. Konopnicki and N. Clumeck 38 Sanne I, Piliero P, Squires K, Thiry A, Schnittman S (2003) Results of a phase 2 clinical trial at 48 weeks (AI424-oo7): a dose-ranging, safety, and efficacy comparative trial of atazanavir at three doses in combination with didanosine and stavudine in antiretroviral-naive subjects.
9th Conference on Retroviruses and Opportunistic Infections, Seattle, Washington, USA, 24-28 February 2002. Abstracts, p 209, no 413-W Margot NA, Johnson A, Cheng A, Coakley DF, Miller MD (2002) Final 48-week genotypic and phenotypic analyses of study 907: tenofovir DF (TDF) added to stable background regimens. 9th Conference on Retroviruses and Opportunistic Infections, Seattle, Washington, USA, 24-28 February 2002. Abstracts, p 209, no 4l4-W Smith MS, Foresman L, Lopez GJ, Tsay J, Wodarz D, Lifson JD, Page A, Wang C, Li Z, Adany I et al.
This history is also characterised by new approaches to treatment research and drug development. Patient associations in USA and Europe have for the first time in medical history contributed to accelerating and changing the process of access to new drugs using pressure on politicians, researchers, clinicians and industry. The regulatory authorities have had to adapt their administrative requirements in order to accelerate the availability of new compounds. The pharmaceutical industry has invested in treatment research but the development of new drugs has mostly been directed towards the developed world.
