By Susan Preston-Martin (auth.), Zbigniew Petrovich MD, FACR, Luther W. Brady MD, Michael L. J. Apuzzo MD, Michael Bamberg MD (eds.)
The American melanoma Society anticipates that 16,500 sufferers should be clinically determined with basic malignant tumors of the significant worried procedure in 2000, with approximately 200,000 participants proposing with mind metastases. The advances within the remedy of strong tumors have contributed considerably to the key bring up in metastatic cancers to the mind. Of the first malignant tumors of the mind, greater than 50% are high-grade gliomas; the prevalence has been expanding between older sufferers during the last decade. significant advancements in new applied sciences within the therapy of basic mind tumors in addition to metastatic disorder are coated extensive. even supposing administration is tough, advances are being made. This ebook is a concerted attempt to give information concerning simple technology study efforts along their translation into scientific perform utilizing mixed, built-in multimodal courses of therapy. development has been made, yet innovatice techniques must be pursued.
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Extra resources for Combined Modality Therapy of Central Nervous System Tumors
Sample text
Undifferentiated lesions may require immunohistochemistry or electron microscopy for identification. A patient will occasionally succumb to a metastatic cerebral lesion for which the corresponding primary lesion could not be found (unknown primary). Cerebral metastatic lesions usually begin at the junction between the gray and white matter. Similar filtrationlike behavior of this junctional area is seen in bacterial abscess formation and fatty emboli. The metastatic lesion is well demarcated from the surrounding brain tissue.
Sem Radiat Oncol 1:2–9 Cooper ERA (1935) The relation of oligocytes and astrocytes in cerebral tumors. J Pathol 41:259–266 Daumas-Duport C, Scheithauer BW, OFallon J, et al. (1988) Grading of astrocytomas. A simple and reproducible method. Cancer 62:2152–2165 Guerrieri C, Jarlsfelt I (1993) Ependymoma of the ovary. A case report with immunohistochemical, ultrastructural, and DNA cytometric findings, as well as histogenetic considerations. Am J Surg Pathol 17:623–632 Hart MN, Petito CK, Earle KM (1974) Mixed gliomas.
The classic posterior fossa lesion characteristically arises as an exophytic mass from the floor of the fourth ventricle. Resulting obstruction of CSF flow will result in hydrocephalus. The tumors are slow-growing low-grade lesions that show local invasion. There is a high rate of local recurrence. A rare lesion may also show metastasis outside of the CNS. Ependymomas are moderately well-circumscribed solid gray masses that may contain calcification, cyst formation, or hemorrhage. Microscopically, they are composed of a neoplastic ependymal cells with mild nuclear pleomorphism (Fig.
