By Carnillo Peracchia (Eds.)
Because the first hole junction protein (connexin) was once cloned over a decade in the past, greater than a dozen connexin genes were cloned. for this reason, a wealth of data at the molecular foundation of hole junctional conversation has been collected. This publication can pay tribute to this intriguing period within the heritage of mobile communique study by way of documenting the nice strides made during this box due to the merging of biophysics and molecular biology, of the main robust techniques to learning the molecular foundation of membrane channel habit. Twenty-eight entire chapters, authored via across the world famous leaders within the box, talk about the biophysical, physiological, and molecular features of cell-to-cell communique through hole junctions. Key features of molecular constitution, formation, gating, conductance, and permeability of vertebrate and invertebrate hole junction channels are highlighted. furthermore, a few chapters specialise in contemporary discoveries that implicate connexin mutations and adjustments of hole junctional communique within the pathogenesis of a number of illnesses, together with the X-linked Charcot Marie enamel demyelinating ailment, a few varieties of inherited sensorineural deafness, malignant transformation, cardiac malformations and arrhythmia, eye lens cataract, and Chagas' affliction.
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Extra info for Gap Junctions: Molecular Basis of Cell Communication in Health and Disease
Example text
Formation of the gap junction intercellular channel requires a 30” rotation for interdigitating two apposing connexons. J. Mol. Biol. 277, 171-177. Perkins, G. , Goodenough, D. , and Sosinsky, G. E. (1998b). Structural considerations for connexon docking. In “Gap Junctions” (R. ), pp. 10s Press, Amsterdam. , Bacon, J. , Davies, J. , Stebbings, L. , Todman, M. , Baines, R. , Barnes, T. , Shaw, J. , Starich, T. , Curtin, K. , and Wyman, R. J. (1998). Innexins: a family of invertebrate gap-junction proteins.
1A). Each oligomer is called a connexon or hemichannef, and each connexon is built from six copies of one or more members of a protein family called the connexins. The functional cell-cell channel is formed by the end-to-end docking of the extracellular domains of the two connexons. Therefore, the gap junction membrane channel can be thought of as a dimer of two hexamers joined together in the gap region. In this manner. the membrane channel extends across both cell membranes. 11. , 1998;and see chapter by Phelan) but the sequences predict a similar folding pattern.
Rhee, S. , and Harris, A. L. (1998). Isoform composition of connexin channels determines selectivity among second messengers and uncharged molecules. J. Biol. Chem 273, 2808-2815. , Abney, J. , and Owicki, J. C. (1984). How a gap junction maintains its structure. Nature 310, 316-318. 1. Gap Junction Structure: New Structures and New Insights 19 Britz-Cunningham, S. , Shah, M. , Zuppan, C. , and Fletcher, W. H. (1995). Mutations of the connexin43 gap junction gene in patients with heart malformations and defects in laterality.
