By Christian Lattermann, Freddie H. Fu (auth.), Johnny Huard, Freddie H. Fu (eds.)
This e-book has been written based on the various physicians and scien tists engaged on the advance of organic methods to supplying cures for plenty of orthopaedic issues in addition to to bettering the therapeutic of many tissues of the musculoskeletal process. the 1st objective of this e-book is to make the language appropriate among the bench scientist and the clinician operating in orthopaedic and activities medication so one can hide particular parts of the orthopaedic self-discipline the place the remedy should be more suitable and/or replaced through the developments in molecular drugs. developments in molecular biology, which surround the learn of the genetic foundation of illness, have produced new diagnostic tools and drug cures for genetic ailments and purchased issues. the expansion within the knowing of human genetics has additionally resulted in the initiation of many human gene remedy experiments. even if many authorized healing scientific trials utilizing this new know-how were played within the final ten years, the 1st scientific trial utilizing this expertise within the zone of orthopaedics used to be played on the college of Pittsburgh.
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Additional info for Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine
Sample text
Tissue Engineering Based on the ex vivo Gene Transfer Approach The ex vivo procedure, which combines myoblast transplantation and gene therapy using an autologous myoblast transfer (AMT), has also been utilized in delivering genes to skeletal muscle. This approach was originally used as an alternative to verify the success of myoblast transfer without immunological problems, since an AMT is performed. 2). 2). This method has been performed using adenovirus (Ad), retrovirus (RV), and HSV-1 carrying reporter genes, and has shown that the transduced myoblasts (isogenic myoblasts) fused and reintroduced the reporter genes into the injected muscle (Salvatori et al.
Experience has also shown the potential importance of cell selection for the delivery system. In synovial cells, the expression of the therapeutic IRAP protein is initially high but declines with time, becoming undetectable around 4 to 6 weeks (Evans and Robbins 1994, 1995a, 1995b). The reason for this decline is unknown; cell death due to natural cellular turnover is a 28 1. Huard possible explanation. We have alternatively investigated whether cells from peripheral tissues, such as skeletal muscle, can be used as a gene delivery vehicle to the joint.
Et al. 1997), and transforming growth factorbeta (TGF-~) on fibroblasts from sheep explants (Spindler, Imro, Mayes, and Davidson 1996). In vitro, the synthesis of collagen and noncollagenous protein has been found to be increased by TGF-~ and increased in a dosedependent manner by EGF (Marui et al. 1997). Furthermore, in vivo studies have recently shown that PDGF, TGF-~, and EGF promoted the healing of the medial collateral ligament (Conti and Dahners 1993; Batten, Hansen, and Dahners 1996; Marui et al.
