By Jen-Chywan Wang, Charles Harris
This well timed quantity presents a accomplished evaluate of glucocorticoids and their function in regulating many facets of body structure and their use within the therapy of ailment. The publication is damaged into 4 sections that commence via giving a basic advent to glucocorticoids and a quick background of the sphere. the second one part will speak about the consequences of glucocorticoids on metabolism, whereas the 3rd part will hide the results of glucocorticoids on key tissues. the ultimate part will talk about basic issues, similar to animal types in glucocorticoid study and medical implications of glucocorticoid examine. that includes chapters from leaders within the box, this quantity may be of curiosity to either researchers and clinicians.
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Extra info for Glucocorticoid Signaling: From Molecules to Mice to Man
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Watson LC, Kuchenbecker KM, Schiller BJ, Gross JD, Pufall MA, Yamamoto KR. The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals. Nat Struct Mol Biol. 2013;20(7):876–83. 87. Danielson M. Structure and function of the glucocorticoid receptor. In: Parker MG, editor. Nuclear hormone receptors: molecular mechanisms, cellular functions, clinical abnormalities. London: Academic; 1991. p. 39–78. 88. Picard D, Salser SJ, Yamamoto KR. A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor.
D. -C. Wang, C. 1007/978-1-4939-2895-8_2 33 34 M. Arango-Lievano et al. nuclear receptors are able to integrate multiple signals giving rise to distinct patterns of gene expression, and rapid non-genomic signaling outcomes yet to be discovered. Converging signaling pathways act in part by altering receptor phosphorylation that fosters the recruitment of interacting co-regulatory molecules in the mitochondria, cytoplasm, synapse and nucleus. This chapter explores how glucocorticoid-mediated allostasis employs rapid non-genomic and slow genomic mechanisms together with ongoing neuronal activity, thus providing a molecular framework for understanding normal and pathological glucocorticoid functions.
