Handbook of Methadone Prescribing and Buprenorphine Therapy by Eliezer Soto MD, Joy Hao MD, PhD (auth.), Ricardo A.

By Eliezer Soto MD, Joy Hao MD, PhD (auth.), Ricardo A. Cruciani, Helena Knotkova (eds.)

Methadone and buprenorphine are the single opioids which are indicated for the administration of either soreness and opioid-related drug dependancy. either current distinct demanding situations to the final practitioner and ache expert, requiring a separate research from the remainder of the medicine within the similar family.

Handbook of Methadone Prescribing and Buprenorphine remedy is a useful advisor to the secure use of those opioids. Authored by means of medical and educational leaders from numerous settings and backgrounds, this e-book comprises chapters on pharmacology, adversarial results, secure rotation from different opioids, cardiac toxicity, prescribing, pharmacokinetics, equianalgesic dose and alternative therapy.

This accomplished textual content presents clinicians, researchers, policy-makers and academicians a source for all of the proper issues in methadone prescribing and buprenorphine therapy.

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Additional resources for Handbook of Methadone Prescribing and Buprenorphine Therapy

Example text

Similarly, no evidence of relapse was seen in patients receiving methadone maintenance who received opioid analgesics for cancer-related pain [11]. In fact, relapse prevention theories would suggest that the stress associated with unrelieved pain is more likely to be a trigger for relapse than adequate analgesia. In one study patients receiving methadone maintenance therapy stated that pain played a substantial role in their initiating and continuing illicit opioid use [12]. A third concern is that the addition of opioid analgesics to methadone maintenance will cause severe respiratory or CNS depression.

Other medications may induce enzyme activity, accelerate its breakdown, increase its rate of clearance, lower the SML, and possibly precipitate an abstinence (withdrawal) syndrome or inhibit this enzyme system, slowing methadone metabolism, raising the SML, and possibly causing methadone toxicity from oversedation and/or respiratory depression [31]. Medications that alkalinize the urine (bicarbonate) decrease the rate of methadone excretion and medications that acidify the urine (vitamin C) increase the rate of excretion.

Therefore, cross-tolerance between methadone used for treating opioid dependence and other opioids used for analgesia may explain why these patients often require higher and more frequent doses of opioid analgesics to achieve adequate pain control. A second concern is that the use of opioid analgesics in patients receiving methadone maintenance may result in relapse to illicit opioid use. There is no evidence that exposure to opioid analgesics in the presence of pain increases rates of relapse in such patients.

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Handbook of Methadone Prescribing and Buprenorphine Therapy by Eliezer Soto MD, Joy Hao MD, PhD (auth.), Ricardo A.
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