By Gerald M. Reaven, Ami Laws
Gerald Reaven, the discoverer of Syndrome X, and a panel of world-class investigators thoughtfully summarize our present knowing of ways insulin resistance and its compensating hyperinsulinemia play a huge function within the pathogenesis and scientific process hypertension and cardiovascular disease-the so-called ailments of Western civilization. those special gurus aspect, for the 1st time, the pathophysiological results and the medical syndromes, except for sort 2 diabetes, relating to insulin resistance. in addition they research the genetic and way of life components that give a contribution to the extensive transformations in insulin motion that exist within the inhabitants at huge. well timed and authoritative, Insulin Resistance: The Metabolic Syndrome X illuminates the whole value of insulin resistance as a massive reason behind high blood pressure, center disorder, and polycystic ovary syndrome.
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BMJ 1984;289:1185–1187. 27. McKeigue PM, Marmot MG. Mortality from coronary heart disease in Asian communities in London. BMJ 1988;297:903. 28. McKeigue PM, Ferrie JE, Pierpoint T, Marmot MG. Association of early-onset coronary heart disease in South Asian men with glucose intolerance and hyperinsulinemia. Circulation 1993;87:152–161. 29. Pais P, Pogue J, Gerstein H, et al. Risk-factors for acute myocardial-infarction in indians—a case-control study. Lancet 1996;348:358–363. 30. Musaiger AO. Diabetes mellitus in Bahrain: an overview.
SUMMARY INTERPRETATION Evidence from migrant studies points to genetic explanations for much of the variation in diabetes and insulin resistance between high-risk ethnic groups such as South Asians and low-risk ethnic groups such as Europeans. Prevalence of diabetes is uniformly high (around 20% in those aged over 35 years) in urban populations of South Asian descent even where migration occurred during the mid-nineteenth century (81). Although it is plausible that an effect of maternal environment could persist over one or two generations after migration, it is unlikely that such an effect would persist five or six generations after migration as an exposure specific to Indians.
US Male Health Professionals The 22,693 men who had participated in the Health Professionals Follow-up Study were surveyed by questionnaire at a mean age of 61 years (5). Five groupings of recalled birth weight were defined. 9 lb). At higher levels of birth weight there was no trend in diabetes prevalence. Native Americans In Pima Native Americans diabetes is common even in young adults, and cohort studies of predictors of diabetes can therefore be undertaken with younger individuals. The 1179 Pimas whose birth weights had been recorded between 1965 and 1972 were examined between ages 20 and 39 yr (6).
