By T. J. C. Van Berkel (auth.), Albert V. G. Bruschke, Johan H. C. Reiber, K. I. Lie, Hein J. J. Wellens (eds.)
A certain assessment of all significant angiographic lipid intervention trials, awarded through their critical investigators. easy mechanisms and methodological points, together with biochemical in addition to angiographic points, are mentioned by means of specialists in those fields. A cautious comparability of all on hand facts allows an research to be made from what may possibly presently be thought of proved, which elements advantage extra research, and which hypotheses may be rejected.
Audience: Clinicians fascinated about the perform of lipid reducing and investigators excited by lipid-lowering scientific trials. Scientists focused on different components of lipid examine and investigators accomplishing coronary angiographic trials designed to check the impression of alternative interventions will discover a wealth of knowledge and sensible instructions during this book.
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Additional resources for Lipid-Lowering Therapy and Progression of Coronary Atherosclerosis
Example text
The relative changes in atherosclerotic lesions on sequential arteriograms are predictive of the clinical events of overall and coronary heart disease mortality, and the combined endpoint of coronary heart disease mortality and confirmed non-fatal myocardial infarction54 • In recent years, it has become apparent that less severe angiographic stenoses may account for up to two thirds of cases of unstable angina or acute myocardial infarction 55 • Ambrose et a1. 56 reported a study of patients with unstable angina who had two sequential arteriograms, revealing that 72% of the lesions that had progressed had less than 50% stenosis on the first arteriogram.
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44. Herrick JB. Clinical features of sudden obstruction of the coronary arteries. lAMA. 1912; 59:2015 - 20. 45. Falk E. Morphologic features of unstable atherothrombotic plaques underlying acute coronary syndromes. Am J Cardiol. 1989;63: 114E- 20E. 46. WiIlerson JT, Golino P, Eidt J, CampbeIl WB, Buja M. Specific platelet mediators and unstable coronary artery lesions: experimental evidence and potential clinical implications. Circulation. 1989;80: 198 - 205. 47. Fuster V, Badimon L, Cohen M, Ambrose JA, Badimon 11, Chesebro J.
