By Bert L. Vallee (auth.), Sanat K. Dhar (eds.)
The articles released during this quantity are in response to the papers del ivered at a convention at the position of steel Ions in organic structures held November 20 and 21, 1972, at Argonne nationwide Laboratory. the aim of the convention used to be to provide to an interdiscipl inary viewers of actual scientists a few fresh advancements illustrating the chemical and environ psychological participation of the heavy steel ions within the organic method. The invited audio system on the convention are exact ists within the fields they describe, and the articles offered listed below are at a degree of curiosity to readers with backgrounds in actual sciences who're no longer necessari Iy doing learn within the components defined. The articles are referenced via 1972, and every so often early 1973, and therefore must also be of worth to analyze staff. it truly is was hoping that the e-book wi II be of specific curiosity to chemists, biologists, employees within the fields of en vironmental technological know-how and publ ic healthiness, as wei I as graduate and senior undergraduate scholars in those discipl ines. The convention was once subsidized through the significant States Universities, Inc. , a consortium of 16 midwestern univer sities, the heart for academic Affairs, Argonne nationwide Laboratory, and the us Atomic power fee. it truly is my excitement to thank the individuals of the convention committee for his or her principles and energetic assist in organizing the conference.
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Extra resources for Metal Ions in Biological Systems: Studies of Some Biochemical and Environmental Problems
Example text
HElM, J. PITHA, C. RICHARDSON, J. M. RIFKIND, Y. SHIN, and E. TARIEN Laboratory of Molecular Aging, National Institutes of Health, Gerontology Research Center, Baltimore City Hospitals, Baltimore, Maryland 21224 The biological process in which nucleic acids are involved generally require the participation of metal ions. The same metal ions which are essential to biological function at one concentration may be harmful at other concentrations. For this reason I shal I not restrict the metals to be discussed to those commonly considered toxic, even though the interest of this symposium is focused upon toxicity.
M. (1971), Subunits in Biological Systems, S. N. Timasheff and G. D. , New York: Marcel Dekker. Lemberg, R. and Barrett, J. (1972), The Cytochromes, New York: demic Press. Aca- Linke, W. , and Diekmann, H. (1972), Arch. , 85, 44. , Klein, M. , and Neilands, J. B. (1972), J. Mol. , 68, 265. Llinas, M. and Neilands, J. B. ,~, 159-165. , Pollack, J. , Ames, B. , and Nei lands, J. B. (1972), J. , _11_1,731. Marks, G. S. (1969), Heme and Chlorophyl I, London: Van Nostrand. Mi Iler, R. E. (1973), Microbial Iron Metabol ism, J.
AI I of these processes require the presence of metal ions and many of them involve the unwinding of the DNA molecule. UNWINDING AND REWINDING OF DNA BY METAL IONS One need only inspect the diagram of DNA (Fig. , to the phosphate groups, wi I I exert quite a different effect than metals binding to the bases, because binding to the bases means competition with hydrogen bonding. 0 Figure 4. 2 amino acid Translation 1 0 mRNA 3 amino acid DNA protein tRNA ribosome mRNA + mRNA Transcription and translation.
