By Mark Lucock
This interesting e-book attracts it material from various proper disciplines that stretch from molecular food, dietary sciences, and food dietetics via to genetics, genomics, and anthropology. It provides an essential portrait of the completely primary position that food has performed and keeps to play in shaping who and what people are, in addition to the place they developed from, and the place they're heading as a species.
Molecular nutrients: nutrients and the Evolution of Humankind:
- Blends assurance of the molecular mechanisms that underpin nutrient-gene interactions with evolutionary theory
- Takes a molecular organic method of challenge fixing, and strikes foodstuff clear of its dietetic and anthropological origins to front traces of genomic research
- Covers key ideas in molecular biology; the –omics revolution and bioinformatics; contemporary human evolution; molecular mechanisms of gene-nutrient interactions; the significance of nutrition and genomics in disorder; the evolution of micronutrient metabolism, protein constitution, and human illness; meals and the human lifecycle; modern nutritional styles; modern laboratory instruments in nutrigenomics and human evolutionary studies
Written by way of an the world over known specialist within the box, Molecular nutrients: food and the Evolution of Humankind is a useful textual content and reference ebook for a variety of academics, scholars, and researchers.
Read or Download Molecular Nutrition and Genomics. Nutrition and the Ascent of Humankind PDF
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Extra resources for Molecular Nutrition and Genomics. Nutrition and the Ascent of Humankind
Example text
Some people are sensitive to salt and possess a genetic predisposition toward developing life-threatening hypertension (high blood pressure). Ten percent of people are affected by salt sensitivity in this way. It has been suggested that our early hunter-gatherer ancestors survived on little salt. However, the agricultural revolution and urbanization led to an increase in salt usage with genetically predisposed individuals developing age-related hypertension (64). Lev-Ran and Porta (64) hypothesize that selection pressures may have favored the emergence of a salt-sensitive, hypertensive genotype.
This positive selection may well have improved the reproductive fitness of C282Y heterozygote carriers; 32% of females of reproductive age who were normal homozygotes for a hemochromatosis mutation had iron deficiency compared with only 21% of heterozygote females of reproductive age. A similar trend in iron deficiency exists for males (45). The deleterious effects of this condition are of late-onset (in the fifth or sixth decade of life), so it seems that C282Y, which represents 85% of all hemochromatosis mutations, may exert a DIRECT DIETARY SELECTION OF A HUMAN METABOLOMIC PROFILE 29 selective advantage during the reproductive phase of the human lifecycle by lowering the complications of premature birth associated with low iron status.
How significant are these “thrifty” genes on Nauru? Well, genes that were selected to confer advantage to islanders now represent the leading cause of nonaccidental death. The so-called “thrifty genotype” hypothesis was actually first put forward to explain modern man’s widespread susceptibility to type 2 diabetes. By default, one can postulate that allelic variants that offer protection against type 2 diabetes are “unthrifty” and have been the subject of selection pressures in the past (70). The peroxisome proliferator-activated receptor-γ (PPARG) nuclear receptor is critical for lipogenesis, energy metabolism, and insulin sensitivity.
