By Mathias Bähr
Editor Bahr (neurology, U. of Gottingen scientific college) and members conceal version platforms, molecular mechanisms and scientific trials in a single quantity. They research neurological issues resembling stroke, Parkinson's illness, amyotrophic lateral sclerosis, and trauma; mobile and molecular mechanisms, together with apoptosis and necrosis, irritation, protein misfolding, axonal progress inhibition, neurogenesis and excitotoxicity; and remedies, together with views for neuroprotective remedies in simple study and medical program. They conceal either in vitro and animal version platforms and cellular/molecular types. additionally they learn attainable destiny learn and treatments. Annotation c2004 booklet information, Inc., Portland, OR"
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Extra resources for Neuroprotection: Models, Mechanisms and Therapies
Example text
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BER seems to be of particular significance in ischemia. During BER, DNA glycosylases excise damaged or modified bases. The thus generated purine and pyrimidine-free sites (AP-sites) are eliminated from the damaged DNA strand by AP-endonucleases (apurinic/apyrimidinic endonucleases) and replaced by DNA-polymerase b and DNA-ligase with a short strand of 1 to 4 nucleotides [147] based on the complementary blueprint of the remaining undamaged strand. Apart from oxidative DNA damage, deamination of cytosine may produce uracil.
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