By John A. Hawley, Juleen R. Zierath
This paintings discusses the emergence of an exercise-deficient phenotype and information the results of workout education on chosen points of substrate metabolism. The function of workout interventions and resistence education programmes for the prevention and therapy of insulin resistance also are covered.
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Sample text
1993; Ibrahimi et al. 1996); (b) plasma membrane fatty acid binding protein (FABPpm), a 40 kDa peripheral membrane protein (Isola et al. 1995); and (c) a family of integral plasma membrane fatty acid transport proteins (FATP) ranging in size from 63 to 70 kDa (FATP1FATP6; Gimeno et al. 2003; Hirsch, Stahl, and Lodish 1998; Schaffer and Lodish 1995). FABPpm and FAT/CD36 have been detected in virtually all tissues examined, while the FATPs exhibit a more restricted pattern of tissue expression (Gimeno et al.
3 Rates of palmitate transport and the subcellular distribution of FAT/CD36 in contracting muscles. (a) Palmitate transport at different rates of muscle contraction (0 = resting muscle). (b) Kinetics of palmitate transport in resting (control) and contracting muscle (20 tetani/min). (c) Subcellular distribution of FAT/CD36 in resting (control) and contracting muscle (20 tetani/min). LDM is low-density membrane (intracellular FAT/CD36 depot) and PM is plasma membrane. Data redrawn from A. , 2000, “Acute regulation of fatty acid uptake involves the cellular redistribution of fatty acid translocase,” J Biol Chem.
A severe form of diabetic nerve disease is a major factor in lower-extremity amputations. • Amputation. Of nontraumatic lower-limb amputations, 60% occur among individuals with diabetes. • Dental disease. About one-third of individuals with diabetes have severe periodontal diseases with loss of gum attachment to the teeth measuring 5 mm or more. • Pregnancy complication. Mothers with diabetes have a greater number of spontaneous abortions, and their babies have an increased risk of major birth defects and of developing diabetes later in life.
