By Joaquim Miguel Oliveira, Rui Luís Reis
This booklet offers regenerative innovations for the therapy of knee joint disabilities. The publication consists of 4 major sections totaling 19 chapters which evaluate the present wisdom at the medical administration and preclinical regenerative thoughts. It examines the position of other natural-based biomaterials as scaffolds and implants for addressing assorted tissue lesions within the knee joint. part one offers an up-to-date and entire dialogue on articular cartilage tissue regeneration. part makes a speciality of the $64000 contributions for bone and osteochondral tissue engineering. part 3 assessment the new advances on meniscus repair/regeneration thoughts. ultimately, part 4 additional discusses the present innovations for remedy of ligament lesions. every one bankruptcy is ready by means of international recognize professional on their fields, so we do firmly think that the proposed ebook can be a reference within the sector of biomaterials for regenerative medicine.
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Extra resources for Regenerative Strategies for the Treatment of Knee Joint Disabilities
Example text
1 A summary of clinical trials regarding synovial knee joint interventions with biomaterials 18 moths 1, 2, 3, 4, 6, 8 and 12 months post-operation 10 years 1 month Time-frame 2008–2014 2013–2015 2010–2015 2011–2013 Period time 26 I. Oliveira et al. 4 27 Final Remarks The synovial knee joint plays an important role as it provides unique movements (flexion, extension and a small degree of medial and lateral rotation) while supporting the body’s weight. To do so, it is composed by different tissues such as bones (femur, tibia, and patella), strong ligaments, joint capsule, bursae, and articular fat pads.
The dGEMERIC acquisition RMI technique is well validated and clinically useful, but requires the administration of an intravenous contrast product and has a long acquisition time [18, 85]. The intravenous administration of Gd-DTPA 2- and is consequent and progressive concentration in cartilage is inversely proportional to the glycosaminoglycan content and is an evaluation method for monitoring cartilage repair procedures [18]. T1p Imaging is dependent of collagen network and glycosaminoglycan content and higher T1p Imaging values are indicative of a damaged cartilage.
Signaling molecules including transforming growth factor (TGF-b), insulin-like growth factor (IGF), bone morphogenetic proteins (BMPs), and to a lesser extent fibroblast growth factors (FGFs) and epidermal growth factor (EGF), can improve chondrogenesis in in vitro studies when used isolated or associated. Important developments are expected in this field [59]. 3 Clinical Management of Articular Cartilage Lesions Fig. A. Vilela et al.
