By V. Di Marzo (auth.)
Reviews of body structure, Biochemistry and Pharmacology
Volume a hundred and sixty 2008
V. di Marzo: Endocannabinoids: Synthesis and Degradation
R. Rivera and J. Chun: organic results of Lysophospholipids
S. J. O’Meara, okay. Rodgers, and C. Godson: Lipoxins: replace and effect of Endogenous Pro-Resolution Lipid Mediators
R.K.P. Benninger, M. Hao, and D. Piston: Multi-photon Excitation Imaging of Dynamic procedures in residing Cells and Tissues
G. Schmitz and M. Grandl: Lipid Homeostasis in Macrophages – Implications for Atherosclerosis
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ATX promotes the proliferation of several cancer cell lines and this increase in proliferation is enhanced in the presence of LPC, suggesting LPA activity is important for the effect (Hama et al. 2004; Umezu-Goto et al. 2002). Another feature shared between LPA and ATX is the ability to stimulate preadipocyte proliferation (Ferry et al. 2003; Pages et al. 2001a). ATX activity and subsequent LPA production also promotes the differentiation of primary preadipocytes and a preadipocyte cell line (Ferry et al.
Blood 102:3665–3667 Allende ML, Sasaki T, Kawai H, Olivera A, Mi Y, van Echten-Deckert G, Hajdu R, Rosenbach M, Keohane CA, Mandala S, Spiegel S, Proia RL (2004) Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. J Biol Chem 279:52487–492 An S, Bleu T, Huang W, Hallmark OG, Coughlin SR, Goetzl EJ (1997a) Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. FEBS Lett 417:279–282 An S, Dickens MA, Bleu T, Hallmark OG, Goetzl EJ (1997b) Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid.
The implantation sites that were present were predominantly located proximal to the cervix. On average, the embryos recovered from these implantation sites were smaller in size relative to embryos isolated from wild-type female mice. Pregnancy was slightly prolonged in LPA3 -deficient mice, and although the number of newborn pups was reduced, they were slightly larger than wild-type pups of the same age. LPA3 expression is upregulated in the luminal endometrial epithelium during a period critical for implantation and the data suggest that maternal LPA3 signaling is crucial for proper embryo implantation and spacing (Ye et al.
