By World Health Organization
This file offers the conclusions reached and suggestions made by way of the contributors of the WHO research staff on Tobacco Product legislation at its 3rd assembly, in which it reviewed 4 heritage papers specifically commissioned for the assembly and which dealt, respectively, with the subsequent 4 issues. 1) the contents and layout beneficial properties of tobacco items: their dating to dependence strength and patron charm; 2)Candy-flavoured tobacco items: study wishes and regulatory suggestions; three) Biomarkers of tobacco publicity and of tobacco smoke-induced overall healthiness results; four) atmosphere greatest limits of poisonous elements in cigarette smoke. The research Group's ideas when it comes to each one subject are set out on the finish of the part facing that topic and total techniques are summarized on the finish. The file is complemented by way of 2 Annexes containing studies and different records coming up from conferences of the WHO clinical Advisory Committee on Tobacco items rules (SACTob) and reviews and different files coming up from conferences of the WHO examine staff on Tobacco items legislation (TobReg)
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Additional resources for Scientific Basis of Tobacco Product Regulation (Technical Report Series) (Technical Report Series)
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Pdf), accessed 2 March 2007. 37. Commonwealth of Massachusetts. An Act Relative to Flavored Cigarettes in the Commonwealth. House No. htm, accessed 2 March 2007). 38. Stanfill SB, Ashley DL. Quantification of flavor-related alkenylbenzenes in tobacco smoke particulate by selected ion monitoring gas chromatography – mass spectrometry. Journal of Agricultural and Food Chemistry, 2000, 48:1298–1306. 39. Stanfill SB, Ashley DL. Solid phase microextraction of alkenylbenzenes and other flavor-related compounds from tobacco for analysis by selected ion monitoring gas chromatography – mass spectrometry.
Chewing tobacco, snuff and snus) is common and has become a leading cause of death in many developing countries (30). In the past, transnational manufacturers have promoted new forms of smokeless tobacco in ways that appeal to youths. 3. Advertisement for Kauai Kolada and Twista Lime flavoured cigarettes (Camel Exotic brand) Source: reproduced, with the permission of the publisher, from reference 15. with increases in use, especially among young people (30). The recent introduction of flavoured smokeless tobacco products may also have greater appeal among youths.
The sum of these metabolites accounts for 90% or more of the dose of nicotine. However, a serious limitation of this approach is the difficulty in collecting a complete 24-hour urine sample, and the technical demands and cost of analysing all of the nicotine metabolites. Cotinine as a biomarker of nicotine intake The presence of cotinine in biological fluids indicates exposure to nicotine. Cotinine is the major proximate metabolite of nicotine. Cotinine is, in turn, extensively metabolized, 3’-hydroxycotinine being the major metabolite of nicotine found in the urine.