By Adrien Albert D.Sc. (Lond.), Ph.D. Medicine (Lond.), F.R.I.C. (auth.)
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Extra info for Selective Toxicity: The physico-chemical basis of therapy
Example text
57 Selectivity through distribution can take place even when the agent is toxic to both economic and uneconomic cells, provided that it is accumulated only by the latter. An example where the economic and uneconomic cells are in different species is illustrated in Plate 1. Some years ago a Frenchman dis- PLATE B 1 Elimination, by early spraying with 10 per cent sulphuric acid, of wild radish from a wheat crop. The strip on left was sprayed at emergence. 0 covered that an aqueous solution of sulphuric acid could safely be sprayed on cereal crops to destroy the weeds (Rabate, 1927).
29 'Sites of loss'. Metabolic change as an early step in excretion. Synergism and antagonism. 4 Metabolic change as an early step in activation. 5 Quantitative aspects of distribution. 57 Selectivity through distribution can take place even when the agent is toxic to both economic and uneconomic cells, provided that it is accumulated only by the latter. An example where the economic and uneconomic cells are in different species is illustrated in Plate 1. Some years ago a Frenchman dis- PLATE B 1 Elimination, by early spraying with 10 per cent sulphuric acid, of wild radish from a wheat crop.
2) is essential for active transport through the intestinal membrane. It is thought that the carrier esterifies this group. g. , 1970). 2 DIFFERENCES IN DISTRIBUTION · 33 At least seven carriers control entry through the mitochondrial membrane. One carrier facilitates entry of succinate, D- and L-malate, malonate, and meso-tartrate anions, but not tartrate, maleate, or fumarate. Another carrier mediates the entry of citrate, cis-aconitate, isocitrate, and D- or L-tartrate, but not fumarate or maleate.
