Stem cell transplantation : biology, processing, and therapy by Anthony Ho; Ronald Hoffman; Esmail D Zanjani

By Anthony Ho; Ronald Hoffman; Esmail D Zanjani

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Tiberghien P, Ferrand C, Lioure B, Milpied N, Angonin R, Deconinck E, Certoux JM, Robinet E, Saas P, Petracca B, et al. (2001). Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft. Blood 97: 63–72. 98. Hacein-Bey-Abina S, von Kalle C, Schmidt M, Le Deist F, Wulffraat N, McIntyre E, Radford I, Villeval JL, Fraser CC, Cavazzana-Calvo M, Fischer A (2003). A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency.

Consequently, there is an urgent need for basic cell biological research, especially based on precise knowledge of molecular and genetic mechanisms, in order to provide a safe background for the use of cultured stem cells in the clinical setting, whether of embryonic or adult origin. Given the present status in stem cell research, it is essential that we keep all options open with regard to investigations into both ESCs and ASCs in order 19 20 1 Clinical Potentials of Stem Cells: Hype or Hope? to appreciate the complexity of their differentiation pathways and of their developmental processes.

Two new pseudopod morphologies displayed by the human hematopoietic KG1a progenitor cell line and by primary human CD34+ cells. Blood 92: 3616–3623. 78. Zhang J, Niu C, Ye L, et al. (2003). Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425: 836–841. 79. Calvi LM, Adams GB, Weibrecht KW, et al. (2003). Osteoblastic cell regulate the haematopoietic stem cell niche. Nature 425: 841–846. 80. Reik W, Dean W, Walter J (2001). Epigenetic reprogramming in mammalian development.

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Stem cell transplantation : biology, processing, and therapy by Anthony Ho; Ronald Hoffman; Esmail D Zanjani
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