By Caroline J. Springer
Melanoma learn united kingdom Centre for melanoma Therapeutics on the Institute of melanoma learn, Sutton, Surrey. Covers gene treatment goals in malignant cells. Comprehensively discusses idea and perform. DNLM: Neoplasms - remedy.
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Extra info for Suicide Gene Therapy, Methods and Reviews
Sample text
Recently, HVJ-AVE anionic liposomes with the envelope that mimics the human immunodeficiency virus (HIV) have been constructed and the LacZ gene was transfected by intrathecal administration to the CNS in primates. Transfection efficiencies of 29–59% in neurons were reported (11). An alternative strategy uses polycations to increase the adenoviral mediated expression of the transgenic protein. Complexation of adenovirus harboring the LacZ gene with PEI allows the selective transfection of biliary epithelia via biliary canulation.
Cancer Res. 60, 657–665. 29. , Melo, J. , and Apperley, J. F. (2000) Absence of in vitro or in vivo bystander effects in a thymidine kinase-transduced murine T-lymphoma. Cancer Gene Ther. 7, 954–962. 30. , et al. (2000) Enhanced green fluorescent proteinfusion proteins of herpes simplex virus type 1 thymidine kinase and cytochrome P450 4B1: applications for prodrug-activating gene therapy. Cancer Gene Ther. 7, 806–812. 31. , Catchpole, J. , and Kennedy, S. C. (2000) The nitroreductase/CB1954 combination in Eptein–Barr virus-positive B cell lines: Induction of bystander killing in vitro and in vivo.
15. Ichikawa, T. and Chiocca, E. A. (2001) Comparative analysis of transgene delivery and expression in tumors inoculated with a replication-conditional or defective viral vector. Cancer Res. 61, 5336–5339. 16. Meck, M. , Wagner, L. , et al. (2001) A virus-directed enzyme prodrug therapy approach to purging neuroblastoma cells from hematopoietic cells using adenovirus encoding rabbit carboxyl esterase and CPT-11. Cancer Res. 61, 5083–5089. Vectors in Suicide Gene Therapy 43 17. , et al. (2001) Adenovirus-mediated gene therapy specific for small cell lung cancer cells using a myc-max binding motif.
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