By Philip Hsien-Lan Kao
Pulmonary high blood pressure (PH) is a disorder of the pulmonary vasculature which explanations correct center failure. it really is recognized that PH reasons major home improvement of the pulmonary arterial vasculature, however the results of this home improvement usually are not well-understood. moreover, there's a dearth of analysis in huge mammals for PH. Modeling of the arteries can be very important within the simulation of deformation because of blood move. present types both don't mirror the microstructure, or are too complicated for medical use. This paintings offers mechanical characterization and research of the artery wall, as well as a constitutive version pushed via the microstructure of the artery.
In this paintings, mechanical characterization of the artery wall is played through multiaxial deformation utilizing a custom-fabricated planar biaxial tester. This attempt gadget offers better constancy than the traditional uniaxial checks. utilizing the knowledge collected from the biaxial tester, traits in facets of the mechanical habit because of PH could be elucidated. in particular, during this paintings, the anisotropy of the elastin protein community has been quantified, with the circumferential course being 1.4x stiffer than the longitudinal path. as well as this new discovering, PH has been proven to a little bit lessen the anisotropy of the pulmonary artery trunk. a brand new microstructurally-based constitutive version for the artery wall used to be built to mirror this discovering. This version makes use of decoupled anisotropy for the elastin and collagen networks, reflecting the genuine habit of the artery wall. The version makes use of a sinusoidal elastic beam to version the collagen fibers, reflecting the microstructure. This microstructural foundation is then tested via histology and correlation of fabric parameters to histological photos. utilizing details from this knowledge, potential destiny research of mechanical habit should be proposed.
Read or Download [Thesis] Biaxial Mechanical Characterization and Microstructure-Driven Modeling of Elastic Pulmonary Artery Walls of Large Mammals under Hypertensive Conditions PDF
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Extra resources for [Thesis] Biaxial Mechanical Characterization and Microstructure-Driven Modeling of Elastic Pulmonary Artery Walls of Large Mammals under Hypertensive Conditions
Example text
C) The effect of changing crimped fiber parameter R l0 . As the radius of gyration is changed, it causes the transition to broaden and 36 become more gradual. 95. Figure 2-7(A-C) show the stress-stretch curves for varying one parameter and holding the others constant. In these figures, λ1 and λ2 correspond to the axial and circumferential stretch, respectively, while λ3 is the radial stretch. In calculating the material response, the uniaxial stretch, λ1 or λ2, is the independent parameter, and σ1, λ2 and λ3 or σ2, λ1 and λ3 are the dependent variables, as in Eq.
The planar biaxial tester uses four independent linear actuators to produce two orthogonal axes of deformation in the sample. There are two independent load channels, one monitoring each axis of deformation. Data is collected using a custom LabView VI. A LabView (National Instruments) interface was supplied by Sacks’ group, but was not updated for the current hardware and software. Thus, the LabView interface was modified to use the current software API and hardware. The software currently runs only load control testing with constant carriage speeds.
The modulus of collagen was chosen to be in the range of previous work [27, 39, 48, 49], with a value of 10 MPa. The model from here on will be called the total crimped fiber (TCF) model. 7 Results In the following, we evaluate the TCF model predictability by investigating the stressstrain response of artery tissue under uniaxial loading conditions. First, the stress-stretch response of the model under uniaxial loading is developed. Second, we conduct parametric studies to observe the effects of structural parameters on the model predictions.
