By Claude Gaillardin, Meriem Mekouar, Cécile Neuvéglise (auth.), Gerold Barth (eds.)
Due to varied distinctive physiological good points and a genome that significantly differs in constitution, gene content material and association from different yeasts, Y. lipolytica is regular as a version organism. With its features, akin to the facility to amass oil and the excessive skill for secretion of proteases and lipases, the yeast is usually of significant curiosity for biotechnological applications.
The major issues lined during this Microbiology Monograph are: comparative genomics; mitochondrial genomics and proteomics, together with the research of the breathing chain; transposable parts and their actions; non-coding RNA genes, which demonstrate a few strange and memorable beneficial properties in comparison to different hemiascomycetes; usage of hydrophobic substrates, of n-alkane and its oxidized derivatives as assets of carbon and effort; ambient pH signalling; comparability of protein households in non-conventional yeasts and S. cerevisiae; and the sulphur metabolism of cheese-ripening yeast.
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Additional resources for Yarrowia lipolytica: Genetics, Genomics, and Physiology
Example text
In this chapter, we are going to review these efforts, with a special emphasis on novel analytical methods that were developed in the course of these studies. Many questions on complex I remain unanswered. Only recently the complex was studied by X-ray crystallography (Hunte et al. 2010; Efremov et al. 2010; Baradaran et al. 2013), and the reaction mechanism is far from being understood. This lack of information is untenable in view of the vital position of complex I in human metabolism, as illustrated by the fact that inherited and acquired complex I defects cause severe, progressive and often fatal disorders, with Leigh syndrome as the most typical clinical manifestation (see below).
Clearly, the X-ray structure of the complex I holoenzyme was required to unambigously elucidate the orientation of the peripheral arm with respect to the membrane arm. Mitochondrial Genomics and Proteomics of Yarrowia lipolytica 41 4 A Genetic Approach to Y. lipolytica Complex I In the following, we report on our efforts to establish Y. lipolytica as a model system for the genetic and proteomic analysis of complex I. Through long years of spadework, a wealth of information has been obtained and a number of methodological approaches have been developed that now allow tackling various aspects of complex I structure, function and assembly.
9 Conclusion The Y. lipolytica is presently the largest Hemiascomycete genome and has been probably one of the most difficult to annotate due to its large size, the relative abundance of introns and the strong sequence divergence of its coding regions. It is nevertheless one of the best annotated genomes among hemiascomycetes except S. cerevisiae, even if annotation is clearly far from being optimal and if many mistakes or erroneous annotations still remain. Our hope was to provide a reference for yeast genomes distantly related to S.
