By Jerome F. Strauss III MD PhD, Robert L. Barbieri MD
Completely revised and now more suitable with colour paintings, the recent version of this foremost reference keeps to supply the most recent details at the prognosis and administration of reproductive endocrine issues. nationwide and foreign leaders from the sector of reproductive endocrinology-including 30 new authors-equip you with insurance that encompasses the whole spectrum of reproductive pathophysiology and problems, from being pregnant and delivery to reproductive getting older. Full-color illustrations and new drawings offer a real-life depiction of uncomplicated telephone constructions and endocrine responses for a greater knowing of the cloth, whereas new chapters discover the problems shaping present day perform. As knowledgeable seek advice identify, it contains handy on-line entry to the whole textual content of the book-fully searchable-along with all the photos, and references associated with Medline at www.expertconsult.com.
- Covers the whole spectrum of reproductive pathophysiology and problems, from being pregnant and delivery to reproductive getting older.
- Includes the paintings of leaders within the box of reproductive endocrinology for information you could trust.
- Features every time, anyplace on-line entry to the entire textual content of the book-fully searchable-as good as the entire photos, and references associated with Medline.
- Offers new content material on maintenance of fertility, endocrine disturbances affecting replica, imaging applied sciences, and adolescent reproductive endocrinology that discover the problems shaping modern practice.
- Includes full-color illustrations and new drawings which supply a real-life depiction of anatomy and cellphone functionality and disorder for a better understanding.
- Provides an inventory of urged readings on the finish of every bankruptcy for additional reference.
- Presents clean insights into contemporary box and destiny advances, in addition to a better overseas viewpoint.
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Extra resources for Yen & Jaffe's Reproductive Endocrinology: Expert Consult - Online and Print, 6e
Sample text
These neurons project to GnRH neurons, stimulating GnRH activity. In the absence of estradiol, Kiss1 neurons are highly active, leading to elevated GnRH/gonadotropin secretion. When estradiol levels rise, Kiss1 activity decreases, leading to a reduction in GnRH activity and gonadotropin secretion. Positive feedback: Kiss1 neurons in the anteroventral periventricular nucleus (AVPV) also express ERα, but they are stimulated by estradiol. They may also receive inputs from the suprachiasmatic nucleus (SCN), which relay time-of-day information and project to GnRH neurons.
Orexins (also known as hypocretins) are produced by neurons whose cell bodies reside in the lateral hypothalamus, and these neuropeptides (orexin-A/hypocretin-1 and orexin-B/hypocretin-2) have been implicated in the neuroendocrine regulation of feeding behavior and the control of sleep–wake cycles, although the nature of their involvement in body weight regulation is a matter of some controversy. Orexins are also known to influence GnRH and LH secretion. Centrally administered orexins stimulate LH secretion.
It is the C-terminal region of the α-GSU, however, that undergoes the greatest change in conformation. When bound to receptor, the C-terminal region rotates nearly 180 degrees, placing it more than α-Subunit (92 aa) H2N 37 20 Å from its position in unbound FSH.
